Both investigators, authors, and grantee institutions have the obligation to ensure that sufficient rights under copyright are reserved to allow full compliance with the NIH Policy, and that the final, peer-reviewed manuscript is submitted to PubMed Central upon acceptance for publication. The Harvard Open Access Policy helps to ensure that Harvard faculty will have automatically retained sufficient rights. When publishing papers that are subject to the NIH Public Access Policy, Harvard faculty members must be careful not to waive their rights to submit their manuscru\ipt into PubMed Central nor sign publishing agreements that would be incompatible with the NIH Policy. This would include, for example, agreements that transfer the entire copyright in your article to the publisher, or that grant the publisher exclusive rights, or contain other restrictions, that prohibit authors' ability to deposit their NIH supported manuscripts into PubMed Central. If you fail to make appropriate modifications to such an agreement, you could breach the agreement and violate the NIH Policy.